Rubio called for economic policy reforms to compete with dozens of other countries for the best jobs, businesses and ideas, and he said the country's tax policies, regulations and national debt are holding the United States back.

Rubio said America must fully utilize its energy resources — and repeal and replace Obamacare with a health care law that allows every American to buy health insurance, with pre-tax money, from companies from any state.

"The world and the economy is changing, and our policies must change with it," Rubio said. "We are not just facing an economic downturn, we're facing an economic transformation."

He also called for flexible college classes for working adults and requiring schools to disclose how much students may earn from a certain degree after graduation — before they take out a student loan.

"I believe we need to have alternative, accredited programs that allow people to get the equivalent of a degree, from alternative institutions, that allow them to package learning, no matter how they acquired it," he said. "Let people learn online for free. Give them credit for what they've learned on their own."

Rubio also called for a stronger stance against five threats: North Korean, Russia, China, Iran and radical jihadists who have spread across multiple Middle Eastern countries, and who recruit Americans online.

"The most important obligation of the federal government is to keep you safe, and me safe, and our families safe, and it's not doing that now because we're eviscerating our defense spending," he said. "We have an Army that just cut 40,000 spots, and a Navy and an Air Force smaller and older than they've been in decades."

Rubio said America must remain the most powerful military force in the world — and have a "foreign policy of clarity."

"One that makes clear to the world that this nation will do whatever it takes to ensure that the only pro-American, free enterprise democracy in the Middle East, the state of Israel, prospers and thrives as the Jewish state," he said.

These changes are within reach, he said. "We can do all three of these things, and if we do, the 21st Century will be the greatest era that America has ever known," he said.